TNFRSF19 / TROY蛋白產(chǎn)品信息

別名: TNFRSF19, TAJ, TROY
表達(dá)方式: 
A DNA sequence encoding the human TNFRSF19 (Q9NS68-2) (Met1-Leu170) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達(dá)宿主: Human Cells

TNFRSF19 / TROY Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Glu 30
分子量: 
The recombinant human TNFRSF19 consists of  152 amino acids and predicts a molecular mass of 16.9 KDa. It migrates as an approximately 28 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFRSF19 / TROY Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFRSF19 / TROY蛋白背景綜述

Tumor necrosis factor receptor superfamily member 19, also known as, Toxicity and JNK inducer, TNFRSF19, TRADE and Troy, is a member of the TNF-receptor superfamily and contains 3 TNFR-Cys repeats. TNFRSF19 is highly expressed in ***** brain, and in embryos from day 11-17, but not earlier. It is detected in embryonic brain and epithelium, and at lower levels in ***** heart, lung and liver. In neonatal mice, TNFRSF19 is mainly expressed in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. TNFRSF19 has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19 is the first TNFRSF member that is identified as a biomarker for melanoma. TNFRSF19 also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies.

參考文獻(xiàn)

Hu S. et al., 1999, Genomics. 62: 103-7.
Eby MT. et al., 2000, J Biol Chem. 275: 15336-42.
Kojima T. et al., 2000, J Biol Chem. 275: 20742-7.
Spanjaard RA. et al., 2007, Int J Cancer. 120 (6): 1304-10.

規(guī)格：100ug

關(guān) 鍵 詞：TNFRSF19 / TROY Protein,使用說(shuō)明,廠(chǎng)家現(xiàn)貨，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠(chǎng)家

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