產(chǎn)品名稱:FITC 小鼠抗小鼠 NK-1.1 抗體；FITC Mouse Anti-Mouse NK-1.1
中文名稱:FITC 小鼠抗小鼠 NK-1.1 抗體
英文名稱:FITC Mouse Anti-Mouse NK-1.1
FITC Mouse Anti-Mouse NK-1.1 產(chǎn)品介紹：
Material Number: 553164
Alternate Name: NKR-P1B and NKR-P1C
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: PK136
Immunogen: Mouse NK-1+ Spleen and Bone Marrow Cells
Isotype: Mouse (C3H x BALB/c) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
FITC Mouse Anti-Mouse NK-1.1 Description：
In the mouse, at least three members of the Klrb (Killer cell lectin-like receptor, subfamily b; formerly NKR-P1) gene family have been
identified (Klrb1a/NKR-P1A, Klrb1b/NKR-P1B, and Klrb1c/NKR-P1C); but in the human gene family, a single homologue has been
designated KLRB1, NKR-P1A, or CD161. The KLRB1/NKR-P1 family of proteins are type-II-transmembrane C-type lectin receptors.
KLRB1C/NKR-P1C activates NK-cell cytotoxicity, while KLRB1B/NKR-P1B functions as an inhibitory receptor. KLRB1B/NKR-P1B
protein has intracellular Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), while KLRB1C/NKR-P1C lacks ITIM and activates via
association with Fc Receptor γ chain. Strikingly, KLRB1B/NKR-P1B and KLRB1C/NKR-P1C share 96% amino acid sequence identity in
their extracellular C-type lectin domains. The PK136 antibody reacts with the NK-1.1 surface antigen encoded by the Klrb1c/NKR-P1C gene
expressed on natural killer (NK) cells in selected strains of mice (eg, C57BL, FVB/N, NZB, but not A, AKR, BALB/c, CBA/J, C3H, C57BR,
C58, DBA/1, DBA/2, NOD, SJL, 129) and the antigen encoded by the Klrb1b/NKR-P1B gene expressed only on Swiss NIH and SJL mice, but
not on C57BL/6. Expression of KLRB1C/NKR-P1C protein is correlated with the ability to lyse tumor cells in vitro and to mediate rejection
of bone marrow allografts. The NK-1.1 marker is useful in defining NK cells; however, the antigen is also expressed on a rare, specialized
population of T lymphocytes (NK-T cells) and some cultured monocytes. Plate-bound PK136 mAb, in combination with low concentrations of
IL-2, induces proliferation of a subset of NK cells.
FITC Mouse Anti-Mouse NK-1.1 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
